PIN1 Provides Dynamic Control of MYC in Response to Extrinsic Signals
نویسندگان
چکیده
منابع مشابه
Pre-Anchoring of Pin1 to Unphosphorylated c-Myc in a Fuzzy Complex Regulates c-Myc Activity.
Hierarchic phosphorylation and concomitant Pin1-mediated proline isomerization of the oncoprotein c-Myc controls its cellular stability and activity. However, the molecular basis for Pin1 recognition and catalysis of c-Myc and other multisite, disordered substrates in cell regulation and disease is unclear. By nuclear magnetic resonance, surface plasmon resonance, and molecular modeling, we sho...
متن کاملDynamic Control of the Yeast AMPK/SNF1 Pathway in Response to Glucose Signals THESIS FOR THE DEGREE OF DOCTOR OF PHILOSOPHY Dynamic control of the yeast AMPK/SNF1 pathway in response to glucose signals
The SNF1/AMP-activated protein kinase (AMPK) belongs to a family of energy sensors that is conserved in all eukaryotes. Activated by ATP depletion, AMPK plays a vital role in restoring the energy balance by enhancing energy-generating and damping energyrequiring processes. Yeast SNF1 is activated by depletion of glucose in the growth medium but is also affected by other environmental stresses s...
متن کاملHarmonic Response of Pile Groups to Dynamic Loading
A completely general method of analysis for three-dimensional raked piles under harmonic excitation is discussed. The piles have been represented by a three-dimensional frame structure and the soil has been represented by a boundary element discretization scheme. A computer program has been written which carries out this analysis and produces a group stiffness matrix that can be included as a f...
متن کاملReduced c-myc expression levels limit follicular mature B cell cycling in response to TLR signals.
The splenic B cell compartment is comprised of two major, functionally distinct, mature B cell subsets, i.e., follicular mature (FM) and marginal zone (MZ) B cells. Whereas MZ B cells exhibit a robust proliferative response following stimulation with the TLR4 ligand LPS, FM B cells display markedly delayed and reduced levels of proliferation to the identical stimulus. The current study was desi...
متن کاملfrom linguistics to literature: a linguistic approach to the study of linguistic deviations in the turkish divan of shahriar
chapter i provides an overview of structural linguistics and touches upon the saussurean dichotomies with the final goal of exploring their relevance to the stylistic studies of literature. to provide evidence for the singificance of the study, chapter ii deals with the controversial issue of linguistics and literature, and presents opposing views which, at the same time, have been central to t...
15 صفحه اولذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Frontiers in Cell and Developmental Biology
سال: 2020
ISSN: 2296-634X
DOI: 10.3389/fcell.2020.00224